1. Noun. (computing) w:Base Class Library Base Class Library ¹
¹ Source: wiktionary.com
Medical Definition of Bcl
1. Two variants of this oncogene are recognised.
1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.
See: ced mutant.
2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.
(24 Mar 1998)
