Definition of Alkylating agent

1. Noun. An antineoplastic drug used to treat some forms of cancer.

Generic synonyms: Antineoplastic, Antineoplastic Drug, Cancer Drug
Specialized synonyms: Chlorambucil, Leukeran

Medical Definition of Alkylating agent

1. A reagent that places an alkyl group, for example propyl in place of a nucleophilic group in a molecule. Alkylating reagents include a number of cytotoxic drugs some of which react fairly specifically with N7 of the purine ring and lead to depurination of DNA, for example the agent ethyl ethanesulphonic acid and thus to mutagenesis. The drugs interaction with DNAand prevents the division of the cells. Examples of drugs include: busulphan, chlorambucil, cyclophosphamide, melphalan. (29 Sep 1997)

Lexicographical Neighbors of Alkylating Agent

alkyl hydroperoxide reductase
alkyl nitrite
alkyl phosphate
alkyl phosphates
alkyl radical
alkylacetylglycerophosphatase
alkylamine
alkylamines
alkylammonium
alkylammoniums
alkylarene
alkylate
alkylated
alkylates
alkylating
alkylating agent (current term)
alkylating agents
alkylation
alkylations
alkylative
alkylbenzene
alkylbenzenes
alkylbenzenesulfonate
alkylbenzoic
alkylborane
alkylboranes
alkyldihydroxyacetone phosphate acyltransferase
alkyldimethylbenzylammonium chloride
alkylene
alkylene oxide

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