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Medical Definition of Scatchard plot
1. A method for analysing data for freely reversible ligand/receptor binding interactions. The graphical plot is: Bound ligand/Free ligand) against (Bound ligand), the slope gives the negative reciprocal of the binding affinity, the intercept on the x axis the number of receptors (Bound/Free becomes zero at infinite ligand concentration). The Scatchard plot is preferable to the Eadie Hoffstee plot for binding data because it is more dependent upon the values at high ligand concentration which will be the most reliable values. A nonlinear Scatchard plot is often taken to indicate heterogeneity of receptors, although this is not the only explanation possible. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)
Lexicographical Neighbors of Scatchard Plot
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